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Linfoma gastrico

 



 

 

 



 

 

 

Generalità


Il linfoma (5% delle neoplasie gastriche) è la più frequente delle neoplasie non epiteliali maligne dello stomaco. Il più frequente linfoma gastrico è il MALT-linfoma (Mucosal- Aassociated-Lymphoid Tissue), tumore del tessuto linfoide associato alle mucose. Il MALT- linfoma consegue all’infezione da Helicobacter pylori. Ne esistono due varianti morfologiche, cliniche e prognostiche: 

  1. Il linfoma gastrico correlato all’infezione da Helicobacter pylori, a cellule B e a basso grado di malignità, tipico del sesso maschile e dell’età avanzata;
  2. Il linfoma gastrico ad alto grado. 

 

Sintomi

 

 I sintomi sono aspecifici e comprendono:

  • Fatica
  • Febbre
  • Nausea
  • Stitichezza
  • Perdita di peso
  • Anemia

Altri sintomi riguardano specificamente gli organi affetti:

  • Dolore addominale nel caso di un coinvolgimento dello stomaco
  • Infezioni polmonari ricorrenti nel caso di un coinvolgimento del polmone
  • Compromissione della vista nei casi di coinvolgimento delle ghiandole lacrimali.
  • In generale i pazienti non presentano linfadenopatia.

 

Diagnosi

La diagnosi si fonda sull’ EGDS (Esofagogastroduodenoscopia)  associata a biopsie su lesioni ulcerate o polipoidi. 

 

Terapia

Il trattamento prevede (come prima scelta) l’eradicazione dell’infezione da H. pylori a cui consegue nella maggioranza dei casi una regressione della neoplasia. La chirurgia o la radioterapia si utilizzano nelle localizzazioni unicamente gastriche non responsive all’ eradicazione o nelle quali la H. pylori non è presente. La  chemioterapia è indicata  in casi con interessamento linfonodale diffuso nei quali trovano indicazione anche anticorpi monoclonali anti linfociti CD20+. Questi linfomi hanno un’evoluzione lenta. Quando un linfoma è isolato, il tasso di sopravvivenza a 10 anni dopo trattamento è circa del 75%.

 

Articoli correlati:

 

Linfomi non-Hodgkin 

LEGGI ARTICOLO


Linfoma mantellare 

LEGGI ARTICOLO


Linfoma B diffuso a grandi cellule (DLBCL) 

LEGGI ARTICOLO


 

Un pensiero su “Linfoma gastrico

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