Infarto miocardico acuto (IMA)
Table of Contents
Definizione
Generalmente l’infarto miocardico acuto è dovuto alla rottura di una placca instabile, con formazione secondaria di un trombo che occlude parzialmente o totalmente il lume della coronaria, provocando un deficit della perfusione a livello distale. Questa è la forma più frequente ed è secondaria a un processo di aterosclerosi. Tra le cause più rare si includono: l’embolia coronarica, il vasospasmo coronarico ( cocaina, ergotamina ecc..),cause iatrogene (chirurgia,interventi percutanei), extracardiache che riducono il flusso coronarico e favoriscono la trombosi (stati di ipercoagulabilità, anemia falciforme, inalazione di CO, ecc..).
Classificazione
Quasi tutti gli infarti colpiscono il ventricolo sinistro.
Possono essere distinti in due differenti tipi:
- Infarto miocardico trasmurale: la parete ventricolare è totalmente interessata.
- Infarto subendocardico: la necrosi ischemica interessa gli strati più interni della parete ventricolare.
Manifestazioni cliniche
La manifestazione clinica più frequente è il dolore toracico di tipo anginoso, ma di maggior durata e più intenso, che appare al riposo e non recede con nitroglicerina sublinguale. Frequentemente si associa a un importante quadro vagale. E’ tipico il suo verificarsi al mattino, dopo che il paziente si è alzato. Il dolore è spesso accompagnato da ansia , agitazione, sudorazione fredda, vomito. Le estremità sono fredde, la pressione arteriosa è normale o bassa, talvolta aumentata durante la fase dolorosa.
Non è infrequente osservare presentazioni cliniche atipiche, come per esempio un dolore epigastrico nell’infarto inferiore, dispnea, sincope non accompagnata da dolore toracico. Le presentazioni tipiche sono più frequenti nei pazienti anziani, nei diabetici e nei pazienti in stato critico o postperati. Le donne hanno una più alta probabilità di presentarsi con un fastidio toracico atipico.
La localizzazione dell’IMA ne determina la prognosi; per esempio un IMA anteriore esteso ha una prognosi peggiore che un IMA Inferiore.
Classificazione di Killip
Grazie all’esame obiettivo si può inoltre classificare l’infarto in base alla classificazione di killip, che
permette una valutazione prognostica.
- Classe I: nessun segno di insufficienza cardiaca ed assenza di 3° tono cardiaco (toni cardiaci)
- Classe II: rumori umidi < 50 % dei campi polmonari con o senza 3° tono cardiaco
- Classe III: rumori umidi > 50 % dei campi polmonari (edema polmonare franco)
- Classe IV: shock cardiogeno (pressione sistolica <90 mmHg, ipoperfusione periferica, oliguria / anuria).
Esami complementari
Un esame fondamentale e in qualunque caso di sospetta sindrome coronarica acuta deve essere effettuato entro 10 minuti dal primo contatto medico.
L’infarto miocardico acuto si può manifestare in due modi:
Infarto miocardico acuto senza sopraslivellamento del tratto ST (NSTEM).
Elettocardigraficamente può presentarsi con:
- ECG normale (almeno in primissima valutazione)
- Sottoslivellamento orizzontale o discendente del tratto ST
- Comparsa di onde T negative -simmetriche
Tale riscontro fa riferimento alla presenza di una lesione subendocardica, non trasmurale, conseguenza di una subocclusione coronarica.
Infarto miocardico acuto con sopraslivellamento del tratto ST (STEMI)
Come indica il suo stesso nome, si manifesta con la presenza di un sopraslivellamento convesso del tratto ST, che traduce la presenza di una lesione transmurale, dovuta all’occlusione completa della coronaria. L’evoluzione ECG prevede la negativizzazione dell’onda T, con la comparsa successiva dell’onda Q di necrosi e progressiva normalizzazione del tratto ST. Se a mesi dall’infarto persistere sopraslivellamento dell’ST bisogna sospettare la presenza di un aneurisma o di una regione discinetica. Il tempo di evoluzione delle alterazioni elettrocardiografiche dipende dalla terapia e dal tempismo con la quale questa venga instaurata. In alcuni casi è possibile riscontare la presenza di un’onda Q durante la loro evoluzione, che indica che si è completata la necrosi transmurale.
Esami di laboratorio
Gli enzimi miocardici che si determinano nella diagnosi dell’IMA sono:
- CK e la sua sezione specifica CK-MB massa. Inizia ad aumentare alle 4-6 ore dall’inizio dell’ischemia, e si normalizza dopo 48-72 ore. La CK aumenta anche in caso di danno muscolare (esercizio fisico, iniezioni intramuscolari, ipotiroidismo, ictus, patologia muscolare). La frazione CK-MB, in particolare CK-MB massa ha una specificità maggiore ma si può comunque elevare in situazioni di danno miocardico di origine ischemica: miocardite, cardioversione elettrica, chirurgia cardiaca e alcune neoplasie.
Altri enzimi che si possono misurare in questo contesto
La mioglobina, che si eleva precocemente alla seconda ora (ma è poco specifica; la GOT e l’ LDH, che iniziano ad aumentare nelle 24 ore hanno un picco tardivo (48 ore e 3-5 giorni rispettivamente), per cui possono essere utili nella diagnosi dell’IMA evoluto.
Altri dati analitici aspecifici
Leucocitosi, iperglicemia, variazioni del profilo lipidico.
Tecniche di imaging
Ecocardiogramma
E’ una tecnica molto utile per valutare le alterazioni della contrattilità segmentaria (le aree necrotiche sono acinetiche mentre quelle ischemiche sono generalmente ipocinetiche) e per escludere la presenza di complicanze (trombi interventricolari, comunicazioni interventricolari,versamento pericardico,aneurisma, valvulopatie).
L’ecocardiogramma, grazie alla grande quantità di informazione che apporta, è utile fin dall’inizio del quadro, e deve essere effettuato in tutti i pazienti in fase acuta per valutare la funzione ventricolare. È l’esame più utilizzato insieme all’elettrocardiogramma nella diagnosi differenziale del dolore toracico acuto.
Gestione dell’infarto miocardico acuto senza sopraslivellamento del tratto ST (NSTEMI)
La trombosi di una placca ateromasica complicata, in base al grado di stenosi che provoca a livello del lume vascolare, provocherà rispettivamente un infarto con sopraslivellamento del tratto ST (di solito occlusione completa dell’arteria), un infarto senza sopraslivellamento del tratto ST (occlusione parziale dell’arteria con elevazione dei marcatori di danno miocardico) o una angina instabile (occlusione parziale del vaso senza elevazione di marcatori di danno miocardico). La gestione dell’angina instabile e dell’infarto senza sopraslivellamento dell’ST è identica ed entrambe le entità vengono inglobate nella sindrome coronarica acuta senza sopraslivellamento del tratto ST.
Terapia
Ricovero e sedazione lieve
Antiaggregazione
- Acido Acetilsalicilico indefinitamente più un secondo antiaggregante ( ticagrelor,prasugel o clopidogrel). Nella SCA-NSTE a rischio molto elevato si può aggiungere un terzo antiaggregante (inibitire della glicoproteina IIb-IIIa: tirofiban o eptifibatide).
Anticoagulazione
- Si utilizzano fondaparinux, eparina sodica o eparina di basso peso molecolare.
Terapia antianginosa
Nitrati, beta-bloccanti e calcio-antagonisti.
Gestione dell’infarto miocardico con sopraslivellamento del tratto ST
La SCA con sopraslivellamento del tratto ST include qualunque caso clinico caratterizzato da sintomi compatibili con ischemia miocardica associata a una elevazione persistente del tratto ST all’ ECG (più di 20 minuti) o a un blocco di branca sinistra di nuova insorgenza. Nella pratica la SCA con sopraslivellamento del tratto ST è sinonimo di IMA con sopraslivellamento del tratto ST, giacchè in tutti i casi si associa un aumento degli enzimi di necrosi miocardica. Lo STEMI è dovuto alla fusione completa di un’arteria conoraria.
La differenza fondamentale con NSTEMI è che in caso di sopraslivellamento si deve realizzare una strategia di riperfusione precoce, in cui il tempo ha un’importanza prioritaria (il tempo definisce la quantità di miocardio salvato). Il massimo beneficio della riperfusione infatti si ottiene le prime 3 ore (soprattutto durante la prima ora) ed è significativo durante le prime 6 ore dall’inizio dei sintomi.
CHIRURGIA
Angioplastica e stent coronarici che dilatano le arterie ostruite, lasciando che il flusso di sangue arrivi più liberamente al cuore.
Intervento chirurgico di bypass coronarico che viene effettuato in casi dove l’angioplastica non dà sufficienti garanzie.
VEDI ANCHE
- Aterosclerosi
- Angina instabile: sintomi, prognosi, terapia
- Angina pectoris
- Dolore toracico
- Edema polmonare
- Sincope
- Emergenza cuore: i consigli da non dimenticare in caso di infarto
I calcio-antagonisti sono una classe di farmaci antipertensivi;bloccano i canali del calcio, riducendo la concentrazione intracellulare di Ca++.
Classificazione
I calcio-antagonisti vengono distinti in tre gruppi:
- Benzodiazepinici (diltiazem)
- Fenilalchilaminici (verapamil)
- Diidropiridinici (nifedipina, amlodipina, felodipina, nicardipina, isradipina, nisoldipina, manidipina,lacidipina, lercanidipina)……LEGGI>
Meccanismi d’azione dei beta-bloccanti
I beta-bloccanti sono farmaci che bloccano i recettori adrenergici beta:
Beta-1
Sono recettori presenti a livello cardiaco, la cui inibizione ha un effetto inotropo e cronotropo negativo.
Beta-2
Sono recettori presenti soprattutto a livello vascolare e bronchiale la cui inibizione provoca
broncocostrizione…. Leggi>
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Impacto mecanico
Sistemas de calibracion: esencial para el operacion estable y eficiente de las maquinas.
En el entorno de la avances avanzada, donde la efectividad y la estabilidad del dispositivo son de suma trascendencia, los equipos de ajuste desempenan un rol crucial. Estos sistemas dedicados estan disenados para ajustar y regular componentes rotativas, ya sea en herramientas de fabrica, vehiculos de traslado o incluso en dispositivos de uso diario.
Para los expertos en mantenimiento de sistemas y los tecnicos, operar con sistemas de balanceo es esencial para garantizar el desempeno suave y fiable de cualquier mecanismo dinamico. Gracias a estas alternativas innovadoras modernas, es posible reducir notablemente las movimientos, el zumbido y la tension sobre los soportes, prolongando la vida util de partes caros.
De igual manera significativo es el rol que juegan los dispositivos de ajuste en la asistencia al cliente. El ayuda especializado y el mantenimiento permanente utilizando estos aparatos habilitan ofrecer asistencias de alta estandar, elevando la contento de los clientes.
Para los duenos de proyectos, la aporte en estaciones de balanceo y medidores puede ser clave para incrementar la efectividad y productividad de sus dispositivos. Esto es particularmente significativo para los inversores que dirigen medianas y intermedias emprendimientos, donde cada aspecto importa.
Por otro lado, los equipos de equilibrado tienen una gran aplicacion en el campo de la prevencion y el gestion de excelencia. Posibilitan identificar eventuales problemas, evitando intervenciones onerosas y danos a los equipos. Incluso, los datos recopilados de estos equipos pueden emplearse para optimizar sistemas y mejorar la visibilidad en buscadores de consulta.
Las campos de uso de los aparatos de ajuste comprenden numerosas industrias, desde la fabricacion de vehiculos de dos ruedas hasta el seguimiento de la naturaleza. No influye si se refiere de importantes elaboraciones productivas o limitados locales de uso personal, los dispositivos de calibracion son indispensables para asegurar un operacion productivo y sin riesgo de fallos.
Comercializamos máquinas para balanceo!
Somos fabricantes, elaborando en tres ubicaciones al mismo tiempo: Portugal, Argentina y España.
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El equipo de equilibrio es transportable, de bajo peso, lo que le permite balancear cualquier eje rotativo en diversos entornos laborales.
Analizador de vibrasiones
El equipo de balanceo Balanset 1A es el resultado de años de trabajo duro y dedicación.
Como desarrolladores de esta herramienta puntera, nos sentimos satisfechos de cada aparato que se envía de nuestras fábricas.
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El equipo de equilibrio es móvil, de bajo peso, lo que le permite balancear cualquier eje rotativo en cualquier condición.
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[b]How to Prevent Dangerous Imbalance and Extend Equipment Lifespan?[/b]
Vibration issues in industrial machinery lead to increased wear, higher energy costs, and unexpected failures. [b]Balanset-1A[/b] is a professional portable balancer and vibration analyzer designed to detect and correct imbalance in rotors, fans, turbines, and other rotating equipment.
[b]Why choose Balanset-1A?[/b]
– High-precision vibration diagnostics
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[url=https://www.amazon.es/dp/B0DCT5CCKT]Full Kit on Amazon[/url]: Balanset-1A device, Vibration sensors, Software & mounting accessories, Hard carrying case
Price: [b]2250€[/b]
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[url=https://www.amazon.es/dp/B0DCT4P7JR]OEM Kit on Amazon[/url]: Balanset-1A device, Basic sensors, Software
Price: [b]1978€[/b]
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Ensure longer equipment lifespan and reduce costly downtime with [b]Balanset-1A[/b].
Key Use Cases
The Balanset-1A is designed for dynamic balancing and vibration diagnostics of rotating machinery .
This versatile device is ideal for:
single- and two-plane balancing of fans, pumps, electric motors, spindles, crushers, centrifuges, and other rotating equipment ,
diagnostic vibration measurement and defect detection ,
enhancing the lifespan of bearings and mechanical assemblies .
Balanset-1A is widely used by service teams, maintenance contractors, repair workshops, industrial plants, and engineering professionals .
Why Choose Balanset-1A
Each Balanset-1A kit includes:
a two-channel measurement unit ,
a pair of industrial accelerometers ,
a laser tachometer (phase sensor) ,
a magnetic holder for secure mounting ,
high-accuracy electronic scales for measuring test and correction weights ,
balancing software (on USB flash drive) ,
a sturdy transportation hard case .
All you need for operation is any notebook running Windows OS .
System Capabilities
Vibrometer Mode:
Vibration phase measurement with ±1° accuracy .
Balancing Mode:
Polar plot display for phase and amplitude .
Advanced Functions:
Intuitive workflow for operators of any skill level .
Commercial Offer
Balanset-1A — EUR 1751
Product page: https://vibromera.eu/product/balanset-1/
Scope of Supply
Dual-channel measurement unit
2 vibration sensors (accelerometers)
Laser tachometer (phase sensor) with reflective tape
Magnetic holder
Electronic scales
Balancing software (USB flash drive)
Sturdy transport case
Delivery and Payment
Worldwide delivery:
CTT Standard (Portugal Post): EUR 36, 7–30 days, https://www.ctt.pt/
EMS Express Mail Service: EUR 250, 4–10 days, https://www.ems.post/
Payment options:
Bank transfer
Credit/Debit card
PayPal
Warranty & Support
1-year warranty: covers any manufacturing defects, with repair or replacement at no extra charge .
Extended technical support (subscription-based):
Direct WhatsApp chat with experts, photo/video troubleshooting, remote software and hardware setup guidance, vibration data interpretation, tailored recommendations for your equipment. Subscribe: https://vibromera.eu/pricing-all/
Contact Information
Website: https://vibromera.eu/shop/2/
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High RTP (98%) ensures fairness
Free demo option for beginners to test the waters
Optimized for flawless mobile play
Negative Aspects
Gameplay can feel repetitive
Lack of diversity and additional options
Delayed responses from support teams
Deceptive advertising
Conclusion
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Rating: A solid 80%
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Strengths and Weaknesses
Positive Aspects
Easytounderstand, quick gameplay
An RTP of 98% guarantees a fair experience
Demo mode for riskfree learning
Optimized for flawless mobile play
Cons
Gameplay can feel repetitive
Lack of diversity and additional options
Delayed responses from support teams
Misleading marketing
Overall Assessment
Chicken Road stands out with its transparency, high RTP, and accessibility. Perfect for relaxed gaming sessions or newcomers to online betting. That said, its focus on chance and limited depth might not satisfy all players. For optimal results, choose verified, legitimate platforms.
Rating: 4/5
A balanced blend of fun and fairness, with potential for enhancement.
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Good Day!
We are pleased to offer high-tech equipment for vibration adjustment of rotor machines – portable balancing device Balanset-1A.
Official product page: https://vibromera.eu/shop/889/
Fields of Use
Balanset-1A is actively applied for balancing of various types rotor units:
Production Mechanisms:
Fans – industrial, exhaust, axial. Pumps – gear, oil. Electric Motors – synchronous. Turbines – hydraulic. Compression Equipment – screw.
Machine Tools:
Spindle Units – lathe. Grinding Wheels. Roll Mechanisms of rolling mills.
Farm Machines:
Threshing Drums. Mulchers. Grinding Equipment for grain.
Specialized Machinery:
Centrifugal Equipment – industrial. Air Blowers. Grinding Equipment. Drive Shafts.
Technical Parameters
Key Characteristics:
Number of balancing planes: 1-2. Operating speed range: 200 to 15,000 revolutions per minute. Phase determination accuracy: ±1°. Vibration error: ±5%. Measurement channels: 2. Vibration velocity measurement range: 0.1 to 300 mm/s. Power: From computer USB port. Equipment mass: 4 kg.
Functionality:
Automatic counting of balancing weights. Database of all balancing procedures. Permissible values computation according to ISO 1940. Spectral analysis of vibration. Graphics in polar coordinates. Split-weight calculator. Eccentricity compensation of mandrels.
Supply Composition
Standard Configuration:
USB coupling module (1 pc.) – ensures measurement control between sensors and computer.
Vibration sensors (2 pcs.) – Sensitivity: 100 mV/g. Frequency range: 0.5-10,000 Hz. Mounting: threaded stud.
Laser phase sensor (1 pc.) – Distance: up to 1.5 m. Contactless operation for operator protection.
Magnetic mount for phase sensor (1 pc.) – Magnetic strength: 60 kgf. Flexible mounting for accurate readings.
Digital scales up to 500 g (1 pc.) – Resolution: 0.01 g. Essential for precise weight measurement.
Program Balanset-1A – Easy-to-use design. Computer software. International versions.
Transport case (1 pc.) – Heavy-duty build. Cushioned interior for safe transport.
Operating instructions – Comprehensive guide. Clear methodology.
Interface cables – High-quality interference-free connections.
Benefits of Balanset-1A
Engineering Strengths:
? Precision Measurements – Innovative technologies of digital filtering provide reliable results.
? Compactness – Easy transportation facilitates on-site balancing without dismantling.
? Versatility – Works with all kinds rotors from compact motors to heavy rotors.
? Simple Operation – Clear controls eliminates need for special training.
Economic Advantages:
? Cost Reduction on maintenance through failure prevention – up to 70% of unplanned downtime.
? Durability Enhancement by 50-200% – balanced equipment lasts longer.
? Power Savings by 5-15% – reduced friction save electricity.
? Quick Payback – from 3 to 12 months depending on usage intensity.
Additional Services
Our company provides:
Specialist Preparation – theoretical sessions at your site. Advanced training includes all aspects.
Consultations – remote guidance. Video conferences for rapid response.
Certification – periodic verification to ensure precision.
Equipment Rental – suitable for trial operations. Weekly rental options available.
Price Information
Actual Prices:
Balanset-1A Portable Balancer & Vibration Analyzer: €1,751.00
Balanset-1A OEM Version: €1,561.00
Additional Vibration Sensor: €90.00
Optical Sensor (Laser Tachometer): €124.00
Magnetic Stand 60 kgf: €46.00
Reflective Tape: €10.00
Shipping Conditions:
Delivery time: in stock. Guarantee period: 24 months comprehensive coverage. Settlement: 50/50. Delivery: worldwide via express delivery.
Why We Stand Out
Official Supplier – original equipment with complete service.
Certified Specialists with extensive experience in predictive maintenance.
Complete Service Cycle – from delivery to support and education.
Stock Availability – quick delivery for common configurations.
Custom Conditions for regular customers including preferred rates.
Best regards,
Technical support team
P.S. Schedule a show of the equipment right now and take advantage of offers!
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